A convenient method for regioselective C-5 halogenation of 4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidines |
| |
Authors: | Charles J Barnett Michael E Kobierski |
| |
Abstract: | N-7, O-Disilylation of 4(3H)-oxo-7H-pyrrolo2,3-d]pyrimidines provides a convenient method for activation of these compounds toward regiospecific halogenation at C-5. The sequence is conveniently carried out without isolation of the silylated derivatives and desilylation is spontaneous upon addition of water to the reaction mixture. |
| |
Keywords: | |
|
|