| Abstract: | The serotonergic neurotransmitter 5-hydroxytryptamine (5-HT), the catecholaminergic neurotransmittcr dopaminc (DA) and various tetrahydroisoquinoline (TIQ) and tetrahydro-β-carboline (THβC) alkaloids are all easily oxidized compounds. Aberrant oxidative transformations of 5-HT and other central indoles might be involved in neurodegenerative Alzheimer's Disease (AD). Changes in the oxidation chemistry of DA appear to be fundamental in substantia nigra neurons in Parkinson's Disease (PD). Various TIQ and THβC alkaloids are elevated in the brain as a result of ethanol drinking. Recent studies into the electrochemical oxidation chemistry of 5-HT, DA and various TIQ and THβC alkaloids have been reviewed. The potential roles of the oxidation chemistry of these compounds in neurodegenerative AD, PD and alcoholism are discussed. |
