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Formation of isoindoline derivatives from o-bromoacetylbenzophenones |
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| Authors: | Seiko Nan'Ya Hirofumi Ishida Yasuo Butsugan |
| Abstract: | o-Dibromoacetylbenzophenone, 2 or o-bromoacetylbenzophenone 3 reacted with aqueous ammonia to produce 3-phenylisoindolin-1-one 5. The reaction of 3 with methylamine afforded 3-hydroxy-2-methyl-3-phenyl-isoindolin-1-one 4 and 2-methyl-3-phenylisoindolin-1-one 5. Whereas from 2 with methylamine only 5 was obtained. |
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