Luminescence diagnostics of malignant tumors in the IR spectral range using Yb-porphyrin metallocomplexes |
| |
Authors: | A V Ivanov V D Rumyantseva K S Shchamkhalov and I P Shilov |
| |
Institution: | 1.Blokhin Russian Cancer Research Center,Russian Academy of Medical Sciences,Moscow,Russia;2.Lomonosov Moscow State Academy of Fine Chemical Technology,Moscow,Russia;3.Kotel’nikov Institute of Radio Engineering and Electronics (Fryazino Branch),Russian Academy of Sciences,Fryazino, Moscow oblast,Russia |
| |
Abstract: | The creation and application of new low-toxic photosensitizers for the luminescence diagnostics of cancer are considered.
The new photosensitizers weakly generate singlet oxygen, exhibit developed luminescence, and retain the tumor-tropic properties
of the therapeutic photosensitizers. Twenty one ytterbium complexes of porphyrin compounds that differ by the substituents
at the periphery of the porphyrin ring are synthesized. The absorption and luminescence spectra and the luminescence decay
curves of these substances are studied. The primary toxicological and pharmacokinetic investigations are performed for the
most promising compounds in the organisms of experimental animals. The experimental data prove that the Yb-porphyrin complexes
are promising as low-toxic markers for the luminescence diagnostics of malignant tumors in the IR spectral range (975–985
nm) that are free of the phototoxicity typical of the conventional porphyrins at a relatively high luminescence contrast and
the selective accumulation in tissue. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|