Penetration of radionuclides across the skin: Glucans as possible inhibitors of metals permeation

Penetration of Cs⁺ , Cd ²⁺ and Co²⁺ions across an animal model of human skin (five-day-old rat skin) was studiedin vitro in vertical diffusion cells. Glucans (fibrilary beta-glucan, carboxymethyl-chitosan-glucan)were used as permeation inhibitors with the aim to reduce the potential toxicologicaleffect of these metals in humans. Of the glucans studied, carboxymethyl-chitosan-glucanwas the more effective inhibitor. The dose-dependency of this effect was demonstrated.