Chemiluminescence determination of sodium 2-mercaptoethane sulfonate by flow injection analysis using cerium(IV) sensitized by quinine |
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Authors: | Capitán-Vallvey L F Valencia Mirón M C Acosta Acosta R |
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Affiliation: | Department of Analytical Chemistry, Faculty of Sciences, University of Granada, 18071 Granada, Spain |
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Abstract: | A flow injection method with chemiluminescence (CL) detection is proposed for the determination of sodium 2-mercaptoethane sulfonate (MESNA), a drug often used to reduce the urotoxic effects of antineoplastic alkylating agents. The procedure is based on the reaction of the thiol with Ce(IV) in a sulfuric acid medium and measurement of the CL intensity produced by quinine used as a sensitizer. The optimum conditions for CL emission were investigated. Using the CL peak height as the analytical parameter, MESNA was determined over the concentration range 0.29–2.21 ng (1.97–9.85 μg·l−1) with a detection limit of 0.21 ng (1.38 μg·l−1) and a relative standard deviation (R.S.D.) of 4.1%. The method was applied satisfactorily to the determination of MESNA in pharmaceutical preparations with percentages of recovery between 94 and 105. |
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Keywords: | Chemiluminescence Sodium 2-mercaptoethane sulfonate Flow injection analysis |
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