Zeolite and sulfated zirconia as catalysts for the synthesis of 5-substituted 1H-tetrazoles via [2+3] cycloaddition of nitriles and sodium azide |
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Authors: | Abbas Teimouri Alireza Najafi Chermahini |
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Affiliation: | a Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Iran b Department of Chemistry, Faculty of Science, Yasouj University, P.O. Box 75918-671671, Yasouj, Iran |
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Abstract: | The [2+3] cycloaddition between various nitriles and sodium azide proceeds smoothly in the presence of zeolite and sulfated zirconia as effective catalysts, in water and DMF/MeOH, to give the corresponding 5-substituted 1H-tetrazoles in good to high yields. The reaction most probably proceeds through the in situ formation of catalyst azide species, followed by a successive [2+3] cycloaddition with the nitriles. This method has the advantages of high yields, simple methodology and easy work-up. The catalyst can be recovered by simple filtration and reused with good yields. |
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Keywords: | Zeolite Sulfated zirconia Green synthesis Tetrazole |
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