|
|||||
|
|
Structure determination and investigation on cytotoxicity of potassium dichlorido(l-prolinato)platinate(II) versus chlorido(dimethyl sulfoxide)(l-prolinato)platinum(II) complex - In vitro antitumor deactivation by Cl/dmso ligand exchange |
|
| Authors: | Rushdi I Yousef Martin BetteGoran N Kalu?erovi? Reinhard PaschkeCui Yiran Dirk SteinbornHarry Schmidt |
| Institution: | a Institut für Chemie der Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, 06120 Halle (Saale), Deutschland, Germany b Chemistry Department, Faculty of Science, Preparatory Year Program, King Faisal University, P.O. Box 380, Al-Ahsaa 31982, Saudi Arabia c Biozentrum, Martin-Luther-Universität Halle-Wittenberg, D-06120 Halle, Weinbergweg 22, Deutschland, Germany d College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, PR China |
| Abstract: | Potassium dichlorido(l-prolinato)platinate(II), KPtCl2(l-pro H)] (1), and chlorido(dimethyl sulfoxide)(l-prolinato)platinum(II), PtCl(l-proH)(dmso)] (2), were synthesized by ligand substitution reactions. Both complexes were characterized by 1H, 13C, and 195Pt NMR spectroscopy, elemental analysis, and HR-ESI-MS. The molecular structures of 1 and 2 were determined by single crystal X-ray diffraction, proving bidentate coordinated l-prolinato ligand and SP-4-4 configuration of 2a. With the help of DFT calculations stability of possible isomers of 1 and 2 was studied. A considerable difference in the in vitro cytotoxicity of 1 versus 2a (exchange of one chlorido ligand by dmso) against four human cancer cell lines was found. |
| Keywords: | Platinum(II) complex l-proline" target="_blank">l-proline X-ray diffraction DFT calculation Antitumor activity |
| 本文献已被 ScienceDirect 等数据库收录！ | |