HSAB principle and nickel(II) ion reactivity towards 1-methyhydantoin |
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Authors: | Mariola Puszyńska-TuszkanowMarek Daszkiewicz Gabriela MaciejewskaZbigniew Staszak Joanna WietrzykBeata Filip Maria Cie?lak-Golonka |
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Affiliation: | a Faculty of Chemistry, Wroc?aw University of Technology, Wybrze?e Wyspiańskiego 27, 50-370 Wroc?aw, Poland b Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, P.O. Box 1410, 50-950 Wroc?aw, Poland c Institute of Informatics, Wroc?aw University of Technology, Wybrze?e Wyspiańskiego 27, 50-370 Wroc?aw, Poland d Ludwik Hierszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Science, Rudolf Weigl Str. 12, 53-114 Wroc?aw, Poland |
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Abstract: | 1-Methylhydantoin and its novel nickel(II) complex [Ni(H2O)4(1-mhyd)2] were prepared and identified, by elemental analysis, single crystal X-ray determination and MS methods. In addition, the complex was characterized by spectroscopic (IR, UV-Vis), magnetic and thermal techniques. The ligand reveals an interesting supramolecular architecture with both classical and non-conventional extended HB bonding networks. All rings and chains formed due to this HB bonding are embedded into the undulated pattern. A single crystal X-ray diffraction analysis of the complex shows that the nickel ion is coordinated by deprotonated hydantoin and water ligands in a N2O4 tetragonal arrangement. In the [Ni(H2O)4(1-mhyd)2] structure both inter and intramolecular hydrogen bonds are created with the participation of water molecules.The ESI-MS method confirmed mono-nuclearity of the complex while electronic spectroscopy proved the tetragonal and pseudooctahedral geometries around the metal ion in the solid state and solution, respectively. By application of the “average environment rule”, 10Dq parameters were obtained for the hypothetical, hexa-coordinate [Ni(1-mhyd)6] approximation or rather more realistic [Ni(1-mhyd)3] chelate. Based on this the mhyd ligand was ranked in the spectrochemical series close to ammonia. The general consideration of the structure of the hydantoin complexes as a function of the metal ion hardness within the framework of the HSAB theory has been provided. Both the ligand and the complex were found to be non-toxic agents against breast (MCF-7), lung carcinoma epithelial (A549) and mouse fibroblasts (Balb/3T3) cancer cell lines. |
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Keywords: | Nickel ion Hydantoin derivative Structure Spectroscopic properties HSAB theory Spectrochemical series |
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