Synthesis of 6-amino-4-aryl-5-cyano-3-(3-cyanopyridin-2-ylthiomethyl)-2,4-dihydropyrano[2,3-c]pyrazoles and their hydrogenated analogs. Molecular structure of 6-amino-5-cyano-3-(3-cyano-4,6-dimethylpyridin-2-ylthiomethyl)-4-(2-nitrophenyl)-2,4-dihydropyrano[2,3-c]pyrazole |
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| Authors: | Rodinovskaya L A Gromova A V Shestopalov A M Nesterov V N |
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| Institution: | (1) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation;(2) A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991 Moscow, Russian Federation |
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| Abstract: | Substituted 3-hydroxypyrazoles, which were prepared based on ethyl esters of substituted 4-(pyridin-2-ylthio)- or 4-(1,4-dihydropyridin-2-ylthio)acetoacetic acids and hydrazine hydrate, were used in the synthesis of 6-amino-4-aryl-5-cyano-3-(pyridin-2-ylthiomethyl)-2,4-dihydropyrano2,3-c]pyrazoles. The molecular and crystal structure of 6-amino-5-cyano-3-(3-cyano-4,6-dimethylpyridin-2-ylthiomethyl)-4-(2-nitrophenyl)-2,4-dihydropyrano2,3-c]pyrazole was established by X-ray diffraction analysis. |
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| Keywords: | malononitrile arylidenemalononitriles 4-(3-cyanopyridin-2-ylthio)acetoacetic esters 6-(3-ethoxycarbonyl-2-oxopropylthio)-1 4-dihydropyridine 2-(pyrazol-5-ylmethylthio)pyridine 2-(pyrazol-5-ylmethylthio)-1 4-dihydropyridine pyrano[2 3-c]pyrazoles X-ray diffraction analysis |
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