| 5-烷氧基-4-环胺基-3-卤-2(5H)-呋喃酮的合成与表征 |
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| 引用本文： | 傅建花,汪朝阳,郝志峰,霍景沛. 5-烷氧基-4-环胺基-3-卤-2(5H)-呋喃酮的合成与表征[J]. 有机化学, 2011, 31(9) |
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| 作者姓名： | 傅建花 汪朝阳 郝志峰 霍景沛 |
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| 作者单位： | 1. 华南师范大学化学与环境学院 广州510006
2. 广东工业大学轻工化工学院 广州510006 |
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| 基金项目： | 国家自然科学基金(No.20772035); 广东省自然科学基金(No.5300082)资助项目 |
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| 摘 要： | 在氟化钾作用下,亲核试剂环状仲胺与5-烷氧基-3,4二卤-2(5H)-呋喃酮在室温下发生串联的迈克尔加成-消除反应,合成了17个新化合物.通过旋光度,UV-Vis,IR,1H NMR,13C NMR,MS,元素分析和X射线单晶衍射等表征方法,确定了目标化合物的化学结构和绝对构型.
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| 关 键 词： | 5-烷氧基-3,4-二卤-2(5H)-呋喃酮 环状仲胺 迈克尔加成 串联反应 5-烷氧基4环胺基-3-卤-2(5H)-呋喃酮 合成 |
Syntheses and Characterization of 5-Alkoxy-4-cycloamino-3-halo-5H-furan-2-one |
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| Fu Jianhua,Wang Zhaoyang,Hao Zhifeng,Huo Jingpei. Syntheses and Characterization of 5-Alkoxy-4-cycloamino-3-halo-5H-furan-2-one[J]. Chinese Journal of Organic Chemistry, 2011, 31(9) |
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| Authors: | Fu Jianhua Wang Zhaoyang Hao Zhifeng Huo Jingpei |
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| Affiliation: | Fu,Jianhuaa Wang,Zhaoyang*,a Hao,Zhifengb Huo,Jingpeia(a School of Chemistry and Environment,South China Normal University,Guangzhou 510006)(b Faculty of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006) |
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| Abstract: | Using cyclic secondary amines as nucleophilic reagents,the tandem Michael addi-tion-elimination of 5-alkoxy-3,4-dihalo-5H-furan-2-one in the presence of potassium fluoride gave 17 novel compounds.The chemical structures and absolute configurations of the new compounds were confirmed via rotation,UV-Vis,IR,1H NMR,13C NMR,MS,elemental analysis and X-ray single crystal diffraction. |
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| Keywords: | 5-alkoxy-3 4-dihalo-5H-furan-2-one cyclic secondary amine Michael addition tandem reac-tion 5-alkoxy-4-cycloamino-3-halo-5H-furan-2-one synthesis |
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