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Some interesting CH_2CH_3 spin systems in several diethyl malonate indene derivatives studied with NMR and molecular modeling |
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| Authors: | ZHANG Long HE WeiWei LIANG YongMin & CUI YuXin State Key Laboratory of Natural Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing China State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou |
| Institution: | ZHANG Long1,HE WeiWei1,LIANG YongMin2 & CUI YuXin1 1 State Key Laboratory of Natural , Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China,2 State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000 |
| Abstract: | While studying the electrophilic cyclization of acetylenic malonates in synthesizing malonate indene derivatives with high regio and stereo-selectivity, we found that the CH2 and CH3 protons of two COOCH2CH3 groups in some diethyl malonate indene derivatives showed very interesting spin-spin coupling and signal multiplicity. To explain those phenomena, we synthesized several diethyl malonate indene derivatives, and then used 1H NMR spectra and molecular modeling to investigate the CH2CH3 spin system of thes... |
| Keywords: | electrophilic cyclization spin-spin coupling signal multiplicity molecular modeling spin system aromatic ring |
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