Studies of 3-O-acyl derivatives of naloxone as its potential prodrugs |
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| Authors: | I. V. Ukrainets A. A. Tkach O. V. Gorokhova A. V. Turov I. V. Linsky |
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| Affiliation: | (1) National University of Pharmacy, Kharkiv, 61002, Ukraine;(2) Taras Shevchenko National University, Kiev, 01033, Ukraine;(3) Institute for Neurology, Psychiatry, and Narcology, Academy of Medical Sciences of Ukraine, Kharkiv, 61068, Ukraine |
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| Abstract: | An efficient method has been proposed for the preparation of a series of 3-O-acyl derivatives of naloxone. The features of the steric structure and NMR spectra are discussed. Pharmaceutical investigation has shown the promise within the synthesized compounds of creating opiate receptor antagonist compounds with prolonged action. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 519–534, April, 2009. |
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| Keywords: | 3-hydroxymorphinans opiate receptor antagonists naloxone prodrugs acylation X-ray structural analysis |
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