Degradation of copolymers obtained by ring-opening polymerization of glycolide and  -caprolactone: A high resolution NMR and ESI-MS study |
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| Authors: | Janusz Kasperczyk Suming Li Joanna Jaworska Piotr Dobrzy&#x;ski Michel Vert |
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| Institution: | aCentre of Polymer and Carbon Materials, 34 Skłodowskiej-Curie Street, 41-800 Zabrze, Poland;bInstitut des Biomolécules Max Mousseron (UMR CNRS 5247), University Montpellier I - University Montpellier II, 15 Avenue Charles Flahault, 34060 Montpellier, France |
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| Abstract: | Electrospray ionization-mass spectrometry (ESI-MS) and proton nuclear magnetic resonance (1H NMR) have been used to investigate the hydrolytic degradation of copolymers obtained by bulk ring-opening copolymerization of glycolide and -caprolactone with monomer ratios ranging from 70/30 to 30/70. NMR allows changes of the average sequence distribution and composition of the components to be followed. In contrast, ESI-MS is able to reveal the detailed chemical structures of various sequences despite the molecular weight limit of 2000 Da. Combination of ESI-MS with NMR can thus provide information to describe microstructure changes during degradation. The distribution of various oligomers shown in the form of planar projections is of great interest for the design of biodegradable system aimed at medical applications. |
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| Keywords: | Degradation Polyglycolide Poly( sciencedirect com/scidirimg/entities/25b -caprolactone)" target="_blank">gif" alt="var epsilon" title="var epsilon" border="0">-caprolactone) Microstructure NMR ESI-MS |
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