Synthesis and antibacterial activity of some novel pyrazolopyridine derivatives |
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Authors: | N. Panda S. Karmakar A. K. Jena |
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Affiliation: | (1) Department of Chemistry, National Institute of Technology, Rourkela, 769008, India |
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Abstract: | Eight pyrazolo[3,4-b]pyridine derivatives have been synthesized by Friedl?nder condensation of 5-aminopyrazole-4-carbaldehyde with active methylene compounds in basic medium. These compounds have been screened for their antibacterial activity against two Gram-negative and two Gram-positive bacterium. Pyrazolopyridines having the carboxamide group at the 5-position showed moderate to good activity against P. aeruginosa, E. coli, S. pneumoniae, and B. cereus. |
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