Atorvastatin ameliorates cerebral vasospasm and early brain injury after subarachnoid hemorrhage and inhibits caspase-dependent apoptosis pathway |
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| Authors: | Gao Cheng Liu Wei Sun Zhi-dan Zhao Shi-guang and Liu Xiang-zhen |
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| Institution: | (1) Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, Heilongjiang, PR China;(2) Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, No.23 Youzheng Street, Nangang District, Harbin, Heilongjiang, PR China |
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| Abstract: | Backgroud Cerebral vasospasm (CVS) and early brain injury remain major causes of morbidity and mortality after aneurysmal subarachnoid
hemorrhage (SAH). Hydroxymethylglutaryl coenzyme A reductase inhibitors, also known as statins, has the neuroprotective effects
and ameliorating CVS after SAH. This study was designed to explore apoptosis inhibiting effects of atorvastatin and its potential
apoptotic signal pathway after SAH. |
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