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Palladium-catalyzed cross-coupling reaction of alkenyl bromides with potassium alkyltrifluoroborates |
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| Authors: | Molander Gary A Ham Jungyeob Seapy Dave G |
| Affiliation: | a Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Campus Box 215, Philadelphia, PA 19104-6323, United States b Department of Chemistry, Eastern University, St. Davids, PA 19087-3696, United States |
| Abstract: | The Suzuki-Miyaura-type cross-coupling reaction of potassium alkyltrifluoroborates with various alkenyl bromides in the presence of 10 mol % of PdCl2(dppf)·CH2Cl2 and 3.0 equiv of Cs2CO3 in aqueous toluene at 80 °C provided the desired compounds in 63-95% yields. A variety of functional groups in the potassium alkyltrifluoroborates were tolerated under the basic conditions. |
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