A fast and highly efficient protocol for Michael addition of N-heterocycles to α,β-unsaturated compound using basic ionic liquid [bmIm]OH as catalyst and green solvent |
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Authors: | Jian-Ming Xu |
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Institution: | Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China |
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Abstract: | A fast and green protocol for the Michael addition of N-heterocycles to α,β-unsaturated compounds at room temperature was developed using a basic ionic liquid, 1-methyl-3-butylimidazolium hydroxide, bmIm]OH, as a catalyst and a reaction medium. The reactions were performed at room temperature with good yields in short reaction times (0.5-3 h). This strategy is quite general and it works with a broad range of N-heterocycles, including five-membered N-heterocycles, pyrimidines and purines. The recovered ionic liquid could be reused for several cycles with consistent activity. |
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Keywords: | Ionic liquid Michael addition N-Heterocycle α β-Unsaturated compounds |
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