1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)-promoted efficient and versatile aza-Michael addition |
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| Authors: | Chang-Eun Yeom |
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| Affiliation: | Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, 151-747, Republic of Korea |
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| Abstract: | A convenient and versatile method was developed for aza-Michael addition using a substoichiometric amount of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Various nitrogen nucleophiles were efficiently introduced to α,β-unsaturated carbonyl compounds employing 0.5 equiv of DBU. Furthermore, other heteroatomic nucleophiles could also be introduced successfully under the same reaction conditions. |
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| Keywords: | Aza-Michael DBU Catalytic Nitrogen nucleophiles Conjugate addition |
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