Aspergiolide A, a novel anthraquinone derivative with naphtho[1,2,3-de]chromene-2,7-dione skeleton isolated from a marine-derived fungus Aspergillus glaucus |
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| Authors: | Lin Du Weiming Zhu |
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| Institution: | Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, PR China |
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| Abstract: | Aspergiolide A (1), an anthraquinone derivative with naphtho1,2,3-de]chromene-2,7-dione skeleton, has been isolated from cultures of a marine-derived fungus Aspergillus glaucus. The structure and stereochemistry of 1 was determined by NMR and X-ray diffraction analyses. Compound 1 showed selective cytotoxicities against A-549, HL-60, BEL-7402, and P388 cell lines. |
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| Keywords: | Aspergillus glaucus Naphtho[1 2 3-de]chromene-2 7-dione Aspergiolide Microorganism Fungus |
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