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Studies on puupehenone-metabolites of a Dysidea sp.: structure and biological activity |
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| Authors: | M. Letizia Ciavatta M. Pilar Lopez Gresa Margherita Gavagnin Dominique Melck Yue-Wei Guo Guido Cimino |
| Affiliation: | a Istituto di Chimica Biomolecolare, CNR, Via Campi Flegrei 34, 80078 Pozzuoli (Na), Italy b Departament de Bioquimica i Biologia Molecular, Facultat de Farmacia, Universitat de Valencia, Avgda Vicent Andrei Estelles s/n, 46100 Burjassot, Spain c State Key Laboratory of Drug Research, Institute of Materia Medica Shanghai, Institutes for Biological Sciences, Chinese Academy of Sciences, 201203 Shanghai, China d Zoologisch Museum, University of Amsterdam, 1090 GT Amsterdam, The Netherlands |
| Abstract: | Puupehenone (1) and a series of its congeners (2-6) have been isolated from a Dysidea sponge. The unprecedented 20-acetoxy-haterumadienone (2) exhibiting a five-membered contracted ring, has been characterized. In addition, stereochemical assignment of two previously reported acetone adducts of puupehenone (5 and 6) has been made. Finally, the inhibition of mitochondrial respiratory chain as well as antibacterial and antifungal activities of all compounds has been evaluated. |
| Keywords: | Sponges Marine metabolites Sesquiterpene-quinones Antifungal Antibacterial Mitochondrial respiratory chain |
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