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Asymmetric synthesis of abietane diterpenoids via B-alkyl Suzuki-Miyaura coupling. Formal total asymmetric synthesis of 12-deoxyroyleanone and cryptoquinone |
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| Authors: | Arata Yajima Ayumi Yamaguchi Fumihiro Saitou Tomoo Nukada Goro Yabuta |
| Affiliation: | Department of Fermentation Science, Faculty of Applied Biological Science, Tokyo University of Agriculture (NODAI), Sakuragaoka 1-1-1, Setagaya-ku, Tokyo 156-8502, Japan |
| Abstract: | A convergent synthetic strategy for abietane diterpenoids via B-alkyl Suzuki-Miyaura coupling and Lewis acid-mediated cyclization reactions is established. Asymmetric total synthesis of 12-deoxyroyleanone, an antileishmanial diterpene, is described. |
| Keywords: | Abietane diterpenes B-Alkyl Suzuki-Miyaura coupling reaction 12-Deoxyroyleanone Cryptoquinone |
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