Allylic and benzylic oxidation reactions with sodium chlorite |
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Authors: | Samuel M Silvestre |
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Institution: | Laboratório de Química Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra, Rua do Norte, 3000-295 Coimbra, Portugal |
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Abstract: | Various allylic and benzylic substrates were selectively oxidized to the corresponding enones in good yields using sodium chlorite, either in combination with tert-butyl hydroperoxide in stoichiometric conditions, or associated with N-hydroxyphthalimide as catalyst. These oxidation reactions were effectively and economically performed under mild, transition-metal free conditions and therefore the dual challenge of cost effectiveness and benign nature of the processes was met with. |
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Keywords: | Sodium chlorite Allylic oxidation Benzylic oxidation Transition-metal free |
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