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Stereoselective synthesis of β-amino ketones via direct Mannich-type reaction catalyzed with silica sulfuric acid |
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| Authors: | Hui Wu Yang Shen Yu Wan Cai-fa Chen |
| Institution: | a Department of Chemistry, Xuzhou Normal University, Xuzhou 221116, PR China b Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou 221116, PR China c Department of Chemistry, Tongji University, Shanghai 200092, PR China |
| Abstract: | At room temperature, the direct Mannich-type reaction of a variety of in situ generated aldimines using aldehydes and anilines with ketones in a three-component reaction was efficiently catalyzed by silica sulfuric acid (SSA) in EtOH. This rapid reaction afforded the corresponding β-amino ketones in good yields with excellent stereoselectivities and catalyst was recyclable. |
| Keywords: | Direct Mannich-type reaction β-Amino ketones Silica sulfuric acid Synthesis |
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