An efficient asymmetric synthesis of manzacidin C |
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| Authors: | Tran Kristy Lombardi Pamela J Leighton James L |
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| Affiliation: | Department of Chemistry, Columbia University, New York, New York 10027, USA. |
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| Abstract: | A brief synthesis of manzacidin C based on a chiral silane-promoted diastereo- and enatioselective acylhydrazone-alkene [3 + 2] cycloaddition reaction has been achieved. This synthesis is the first synthesis of any of the manzacidins wherein the C(4) and C(6) stereocenters are established in a single highly stereoselective step. |
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