In vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) fibres and porous ultra-fine poly(glycolic acid) fibres |
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| Authors: | Young You Sung Won Lee Ji Ho Youk Byung-Moo Min Seung Jin Lee Won Ho Park |
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| Institution: | aDepartment of Textile Engineering, Chungnam National University, 220 Gungdong, Yuseong-ku, Daejeon 305-764, South Korea;bDepartment of Advanced Fibre Engineering, Division of Nano-Systems, Inha University, Incheon 402-751, South Korea;cDepartment of Oral Biochemistry, College of Dentistry, Seoul National University, Seoul 110-749, South Korea;dCollege of Pharmacy, Ewha Wowans University, Seoul 120-750, South Korea |
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| Abstract: | The in vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) (PGA/PLA) fibres and porous ultra-fine PGA fibres was investigated. The non-porous ultra-fine PGA/PLA fibres were prepared by electrospinning of a PGA/PLA solution in 1,1,1,3,3,3-hexafluoro-2-propanol and the porous ultra-fine PGA fibres were obtained from them via selective removal of PLA with chloroform. Since PLA has a lower degradation rate than PGA, the degradation rates of the ultra-fine PGA/PLA fibres decreased with increasing content of PLA. The porous ultra-fine PGA fibres were degraded in vitro in the order of non-porous PGA > P-PGA/PLA(90/10) > P-PGA/PLA(70/30) > P-PGA/PLA(50/50) > P-PGA/PLA(30/70) due to autocatalytic hydrolysis. |
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| Keywords: | Poly(glycolic acid) Poly(l-lactic acid) Electrospinning Porous ultra-fine fibre Biodegradability |
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