| A New Route for the Synthesis of N-Substituted Diketopiperazine Derivatives |
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| 引用本文： | Xi GONG Xiao Xiao YANG De Xin WANG. A New Route for the Synthesis of N-Substituted Diketopiperazine Derivatives[J]. 中国化学快报, 2006, 17(4): 469-472 |
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| 作者姓名： | Xi GONG Xiao Xiao YANG De Xin WANG |
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| 作者单位： | Institute of Materia Medica, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100050 |
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| 基金项目： | The authors would like to thank Dr. Jeper Abliz and his assistants for providing mass spectral data. |
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| 摘 要： | Eight N-substituted diketopiperazines (DKPs) were synthesized by solid-phase protocols. The introduction of iminodiacetic acid (Ida) and followed another α-amino acid residue as the precursor of DKP framework made the present synthesis to be very facile and efficient.
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| 关 键 词： | 二酮哌嗪 亚氨基乙酰乙酸 固相合成 药物化学 生物活性 medicinal chemistry． |
| 收稿时间： | 2005-09-30 |
A New Route for the Synthesis of N-Substituted Diketopiperazine Derivatives |
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| Xi GONG,Xiao Xiao YANG,De Xin WANG. A New Route for the Synthesis of N-Substituted Diketopiperazine Derivatives[J]. Chinese Chemical Letters, 2006, 17(4): 469-472 |
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| Authors: | Xi GONG Xiao Xiao YANG De Xin WANG |
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| Abstract: | |
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| Keywords: | Diketopiperazine iminodiacetic acid solid-phase synthesis. |
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