Diastereoselective multicomponent synthesis and anti-HSV-1 evaluation of dihydrofuran-fused derivatives |
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Authors: | Angela Scala Massimiliano Cordaro Francesco Risitano Ivana Colao Assunta Venuti Maria Teresa Sciortino Patrizia Primerano Giovanni Grassi |
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Affiliation: | Dipartimento di Chimica Organica e Biologica, Università di Messina, Messina, Italy. |
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Abstract: | Enolizable 6-membered cyclic 1,3-dicarbonyls undergo an efficient and diastereoselective domino condensation/addition/heterocyclization reaction with arylaldehydes and phenacyl chloride, producing highly substituted dihydrofuran-fused derivatives. Ring size of the cyclic 1,3-dicarbonyls and the presence of at least one keto group are crucial to the reaction's success. The new compounds were evaluated in vitro for antiviral activity against herpes simplex virus type-1 (HSV-1). Interestingly, some of them appeared able to interfere with HSV-1 replication, without detection of cytotoxic effects. |
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