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| 焦脱镁叶绿酸的Knoevenagel反应及其杂环取代衍生物的合成 | |
| 引用本文： | 王进军,邬旭然,韩光范,沈荣基. 焦脱镁叶绿酸的Knoevenagel反应及其杂环取代衍生物的合成[J]. 有机化学, 2005, 25(3): 313-318 |
| 作者姓名： | 王进军 邬旭然 韩光范 沈荣基 |
| 作者单位： | 1. 烟台大学,应用化学系,烟台,264005 2. 江苏科技大学,镇江,212003 3. 仁济大学,微工程学院,釜山,韩国 |
| 摘 要： | 以焦脱镁叶绿酸-d甲酯(MPPd)为起始原料, 通过其醛基与连有五元杂环的β-二酮、α-氰基酮和丙二腈的活性亚甲基进行Knoevenagel反应, 完成3-位五元杂环取代的焦脱镁叶绿酸-a甲酯衍生物. 所合成的新化合物均经UV, IR, 1H NMR及元素分析证明其结构. |
| 关 键 词： | 焦脱镁叶绿酸 Knoevenagel反应 光动力疗癌法(PDT) |
| 收稿时间： | 2004-05-10 |
| 修稿时间： | 2004-05-10 |
Knoevenagel Reaction of Pyropheophorbide and Synthesis of Its Heterocyclo-substituted Derivatives |
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| WANG Jin-Jun,WU Xu-Ran,HAN Guang-Fan,SHIM Young Key. Knoevenagel Reaction of Pyropheophorbide and Synthesis of Its Heterocyclo-substituted Derivatives[J]. Chinese Journal of Organic Chemistry, 2005, 25(3): 313-318 | |
| Authors: | WANG Jin-Jun WU Xu-Ran HAN Guang-Fan SHIM Young Key |
| Affiliation: | ( Department of Applied Chemistry, Yantai University, Yantai 264005)( University of Science and Technology of Jiangsu, Zhenjiang 212032) (School of Nano Engineering, Inji University, Pusan, Ko-rea) |
| Abstract: | Methyl pyropheophorbide-d was used as starting material and the Knoevenagel reaction of the aldehyde group on pyropheophorbide with active methylene group in β-diketone, α-cyanoketone or malono- nitrile was carried out to complete the synthesis of derivatives of methyl pyropheophorbide-a substituted with five-membered heterocycle at 3-positipon. The structures of all these new compounds were characterized by elemental analysis, UV, IR and 1H NMR spectra. |
| Keywords: | pyropheophorbide Knoevenagel reaction photodynamic therapy |
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