Immobilized triazine-type dehydrocondensing reagents for carboxamide formation: ROMP-Trz-Cl and ROMP(OH)-Trz-Cl |
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| Authors: | Hioki Kazuhito Kameyama Satomi Tani Shohei Kunishima Munetaka |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 650-8586, Japan. |
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| Abstract: | New triazine-type dehydrocondensing reagents, such as ROMP-Trz-Cl and ROMP(OH)-Trz-Cl, were synthesized by a ring opening metathesis polymerization (ROMP) method, and these showed higher loading than conventional polymer-supported condensing reagents. These polymers effect the formation of amides in good yields by addition of a mixture of carboxylic acid, amine and NMM. ROMP(OH)-Trz-Cl, which contains hydroxyl groups in the polymer chain, gave amides in good yields even in MeOH. |
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