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Novel Synthesis of N-Substituted p-Hydroxybenzoic Amides on Soluble Polymer-Support
作者姓名:胡春玲  陈祖兴  杨桂春
作者单位:FacultyofChemistryandMaterialScience,HubeiUniversity,Wuhan,Hubei430062,China
基金项目:ProjectsupportedbytheEducationDepartmentofHubeiProvince ,China (No .2 0 0 1A0 10 17)
摘    要:The synthesis of N-substituted p-hydroxybenzoic amides using a liquid phase approach is described. Poly(ethylene glycol)(PEG) and p-hydroxybenzoic acid were linked by oxalyl chloride to give compound 1, which was chlorinated by thionyl chloride, followed by amidation with NHR^1R^2 to yield compound 3. Hydrolysis of compound 3 gave the title amide 4.These crude library members were obtained in good yields with high purities.

关 键 词:合成  N-取代P-羟基苯酰胺  溶液聚合  聚乙二醇

Novel Synthesis of N-Substituted p-Hydroxybenzoic Amides on Soluble Polymer-Support
HU,Chun-Ling CHEN,Zu-Xing YANG,Gui-ChunFaculty of Chemistry and Material Science,Hubei University,Wuhan,Hubei ,China.Novel Synthesis of N-Substituted p-Hydroxybenzoic Amides on Soluble Polymer-Support[J].Chinese Journal of Chemistry,2003,21(11):1494-1496.
Authors:HU  Chun-Ling CHEN  Zu-Xing YANG  Gui-ChunFaculty of Chemistry and Material Science  Hubei University  Wuhan  Hubei  China
Institution:HU,Chun-Ling CHEN,Zu-Xing YANG,Gui-ChunFaculty of Chemistry and Material Science,Hubei University,Wuhan,Hubei 430062,China
Abstract:The synthesis of N -substituted p -hydroxybenzoic amides using a liquid phase approach is described. Poly(ethylene glycol) (PEG) and p -hydroxybenzoic acid were linked by oxalyl chloride to give compound 1,which was chlorinated by thionyl chloride,followed by amidation with NHR 1R 2 to yield compound 3. Hydrolysis of compound 3 gave the title amide 4. These crude library members were obtained in good yields with high purities.
Keywords:amide  poly(ethylene glycol)  synthesis
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