| Novel Synthesis of N-Substituted p-Hydroxybenzoic Amides on Soluble Polymer-Support |
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| 作者姓名： | 胡春玲 陈祖兴 杨桂春 |
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| 作者单位： | FacultyofChemistryandMaterialScience,HubeiUniversity,Wuhan,Hubei430062,China |
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| 基金项目： | ProjectsupportedbytheEducationDepartmentofHubeiProvince ,China (No .2 0 0 1A0 10 17) |
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| 摘 要： | The synthesis of N-substituted p-hydroxybenzoic amides using a liquid phase approach is described. Poly(ethylene glycol)(PEG) and p-hydroxybenzoic acid were linked by oxalyl chloride to give compound 1, which was chlorinated by thionyl chloride, followed by amidation with NHR^1R^2 to yield compound 3. Hydrolysis of compound 3 gave the title amide 4.These crude library members were obtained in good yields with high purities.
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| 关 键 词： | 合成 N-取代P-羟基苯酰胺 溶液聚合 聚乙二醇 |
Novel Synthesis of N-Substituted p-Hydroxybenzoic Amides on Soluble Polymer-Support |
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| HU,Chun-Ling CHEN,Zu-Xing YANG,Gui-ChunFaculty of Chemistry and Material Science,Hubei University,Wuhan,Hubei ,China.Novel Synthesis of N-Substituted p-Hydroxybenzoic Amides on Soluble Polymer-Support[J].Chinese Journal of Chemistry,2003,21(11):1494-1496. |
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| Authors: | HU Chun-Ling CHEN Zu-Xing YANG Gui-ChunFaculty of Chemistry and Material Science Hubei University Wuhan Hubei China |
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| Institution: | HU,Chun-Ling CHEN,Zu-Xing YANG,Gui-ChunFaculty of Chemistry and Material Science,Hubei University,Wuhan,Hubei 430062,China |
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| Abstract: | The synthesis of N -substituted p -hydroxybenzoic amides using a liquid phase approach is described. Poly(ethylene glycol) (PEG) and p -hydroxybenzoic acid were linked by oxalyl chloride to give compound 1,which was chlorinated by thionyl chloride,followed by amidation with NHR 1R 2 to yield compound 3. Hydrolysis of compound 3 gave the title amide 4. These crude library members were obtained in good yields with high purities. |
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| Keywords: | amide poly(ethylene glycol) synthesis |
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