| 具有红色荧光性质的掺硒碳点在生物传感和抗菌中的多功能应用 |
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| 引用本文： | 厉圆圆,卢修联,刘欣雨,张磊,景苏. 具有红色荧光性质的掺硒碳点在生物传感和抗菌中的多功能应用[J]. 无机化学学报, 2024, 40(1): 173-181 |
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| 作者姓名： | 厉圆圆 卢修联 刘欣雨 张磊 景苏 |
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| 作者单位： | 南京工业大学化学与分子工程学院, 南京 211816 |
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| 基金项目： | 国家自然科学基金(No.22175090，22374075)和江苏省重点研发计划基金(No.BE2021712)资助。 |
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| 摘 要： | 以易得的苯亚硒酸(BA)和邻苯二胺(o-PDA)作为前体，通过一步水热法成功设计并合成了掺杂硒的碳点(Se-CDs)。制备的Se-CDs发出红色波段的荧光，并被用于开发一种检测microRNA-21(miR-21)的灵敏荧光传感器。通过脱氧核糖核酸酶Ⅰ(DNase Ⅰ)介导的信号放大方法，将miR-21的检测限从78 nmol·L-1改进到了6.8 nmol·L-1。此外，Se-CDs对大肠杆菌等革兰氏阴性菌具有理想的抑制活性。
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| 关 键 词： | 掺硒碳点 红色荧光 生物传感 microRNA-21 抗菌 |
| 收稿时间： | 2023-10-02 |
| 修稿时间： | 2023-12-17 |
Red-emitting selenium-doped carbon dots for versatile applications in biosensing and antibacterial activities |
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| LI Yuanyuan,LU Xiulian,LIU Xinyu,ZHANG Lei,JING Su. Red-emitting selenium-doped carbon dots for versatile applications in biosensing and antibacterial activities[J]. Chinese Journal of Inorganic Chemistry, 2024, 40(1): 173-181 |
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| Authors: | LI Yuanyuan LU Xiulian LIU Xinyu ZHANG Lei JING Su |
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| Affiliation: | School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China |
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| Abstract: | In this study, we successfully designed and synthesized selenium-doped carbon dots (Se-CDs) using easily available precursors of benzeneseleninic acid (BA) and o-phenylenediamine (o-PDA) through a one-step hydrothermal method. These Se-CDs emitted red-wavelength fluorescence and were utilized to develop a sensitive fluorescence sensor for detecting microRNA-21 (miR-21). By incorporating deoxyribonuclease Ⅰ (DNase Ⅰ)-mediated signal amplification, the detection limit for miR -21 was improved from 78 to 6.8 nmol·L-1. Furthermore, we observed desirable inhibitory activity of the Se-CDs against Gram-negative bacteria of Escherichia coli (E. coli). |
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| Keywords: | selenium-doped carbon dots red fluorescence biosensing microRNA-21 antibacterial |
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