| A Novel Polybrene/Chondroitin Sulfate C Double Coated Capillary and Its Application in Capillary Electrophoresis |
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| 作者姓名： | 杜迎翔 HONDA Susumub TAGA Atsushib 刘文英 SUZUKI Shigeo |
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| 作者单位： | DU，Ying-Xiang，a，b HONDA，Susumu b TAGA，Atsushi b LIU，Wen-Ying cSUZUKI，Shigeo b a Department of Analytical Chemistry，China Pharmaceutical University，Nanjing，Jiangsu 210009，China b Faculty of Pharmaceutical Sciences，Kinki University，Higashi-Osaka 577-8502，Japan c Department of Pharmaceutical Analysis，China Pharmaceutical University，Nanjing，Jiangsu 210009，China |
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| 摘 要： | ＩｎｔｒｏｄｕｃｔｉｏｎＣａｐｉｌｌａｒｙｅｌｅｃｔｒｏｐｈｏｒｅｓｉｓ (ＣＥ)ｈａｓｂｅｃｏｍｅａｎｉｍ ｐｏｒｔａｎｔｓｅｐａｒａｔｉｏｎｔｏｏｌｂｅｃａｕｓｅｉｔｃａｎｔａｋｅａｄｖａｎｔａｇｅｓｏｆｈｉｇｈｒｅｓｏｌｕｔｉｏｎ ,ｒｅｌａｔｉｖｅｌｙｆａｓｔｓｅｐａｒａｔｉｏｎ ,ｃｏｎｖｅｎｉｅｎｔｓｅ ｌｅｃｔｉｏｎｏｆｓｅｐａｒａｔｉｏｎｃｏｎｄｉｔｉｏｎ ,ａｎｄｅｘｔｒｅｍｅｌｙｓｍａｌｌｖｏｌ ｕｍｅｏｆｓａｍｐｌｅａｎｄｓｅｐａｒａｔｉｏｎｍｅｄｉａ .1 3 Ｖａｒｉｏｕｓｓｅｐａｒａｔ…
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A Novel Polybrene/Chondroitin Sulfate C Double Coated Capillary and Its Application in Capillary Electrophoresis |
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| DU,Ying-Xiang,a,b HONDA,Susumu b TAGA,Atsushi b LIU,Wen-Ying cSUZUKI,Shigeo b a.A Novel Polybrene/Chondroitin Sulfate C Double Coated Capillary and Its Application in Capillary Electrophoresis[J].Chinese Journal of Chemistry,2002,20(12):1557-1565. |
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| Authors: | DU Ying-Xiang a b HONDA Susumu b TAGA Atsushi b LIU Wen-Ying cSUZUKI Shigeo b a |
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| Institution: | DU,Ying-Xiang,a,b HONDA,Susumu b TAGA,Atsushi b LIU,Wen-Ying cSUZUKI,Shigeo b a Department of Analytical Chemistry,China Pharmaceutical University,Nanjing,Jiangsu 210009,China b Faculty of Pharmaceutical Sciences,Kinki University,Higashi-Osaka 577-8502,Japan c Department of Pharmaceutical Analysis,China Pharmaceutical University,Nanjing,Jiangsu 210009,China |
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| Abstract: | A new capillary coated by double polymer, polybrene/chondroitin sulfate C (P/CC), was developed using a simple procedure. The P/CC double coated capillary showed long lifetime, strong chemical stability and good reproducibility. It endured during more than 100 replicated analyses and was also tolerant to HCl (1 mol/L), NaOH (0.01 mol/L), CH 3OH and CH 3CN. The P/CC double coated capillary can be applied to basic drug analyses. The adsorption of basic drugs to the capillary wall was suppressed and the peak tailing greatly decreased. The use of the P/CC double coated capillary allowed excellent separation of the enantiomers of some basic drugs by using chondroitin sulfate C as the chiral selector, and the peak symmetry of basic drugs was further improved under these conditions. |
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| Keywords: | capillary electrophoresis anionic capillary coating basic drug chiral separation chondroitin sulfate C |
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