Liposomal Form of Tetra(Aryl)Tetracyanoporphyrazine: Physical Properties and Photodynamic Activity In Vitro |
| |
Authors: | Andrey V. Yudintsev Natalia Yu. Shilyagina Darya V. Dyakova Svetlana A. Lermontova Larisa G. Klapshina Evgeniy L. Guryev Irina V. Balalaeva Vladimir A. Vodeneev |
| |
Affiliation: | 1.Lobachevsky University,Nizhny Novgorod,Russia;2.G.A. Razuvaev Institute of Organometallic Chemistry of the Russian Academy of Sciences,Nizhny Novgorod,Russia;3.Sechenov First Moscow State Medical University,Moscow,Russia |
| |
Abstract: | Tetra(aryl)tetracyanoporphyrazines are the promising group of dyes for photodynamic therapy of tumors with unique combination of photosensitizer properties and sensitivity of fluorescence parameters to the environment viscosity. However, in vivo application of such hydrophobic photosensitizers requires using of drug carriers ensuring efficient delivery to the tumor site. The present study is focused on obtaining liposomes loaded with tetrakis(4-benzyloxyphenyl)tetracyanoporphyrazine and examining their properties depending on lipid composition. An efficient loading of the dye and a high long-term stability were proved for the liposomes composed of phosphatidylcholine with cholesterol and phosphatidylglycerol. This can be explained by the presence of negatively charged lipids in the bilayer and, as a consequence, a high value of the surface potential. A high rate of cellular uptake and a strong photoinduced toxicity give the prerequisites for the further use of the liposomal form of the photosensitizer for photodynamic therapy of tumors. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|