Palladium-catalyzed cross-coupling reactions of organogold(I) phosphanes with allylic electrophiles |
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Authors: | Peña-López Miguel Ayán-Varela Miguel Sarandeses Luis A Pérez Sestelo José |
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Institution: | Departamento de Química Fundamental, Universidade da Coru?a, E-15071 A Coru?a, Spain. |
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Abstract: | Aryl and alkenylgold(I) phosphanes react regioselectively with allylic electrophiles such as cinnamyl and geranyl halides (bromide, chloride and acetates) under palladium catalysis in THF at 80 °C to afford the α-substitution product with moderate to high yields. When the reaction is performed with a chiral enantiopure secondary acetate, the α-substituted cross-coupling product is obtained with complete inversion of the stereochemistry. |
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