A Seoul-Fluor-based bioprobe for lipid droplets and its application in image-based high throughput screening |
| |
| Authors: | Kim Eunha Lee Sanghee Park Seung Bum |
| |
| Institution: | Department of Chemistry/Bio-MAX Institute, Seoul National University, Seoul 151-747, Korea. |
| |
| Abstract: | We developed a novel fluorescent bioprobe (SF44) that can specifically visualize the cellular lipid droplets in in vitro and in vivo systems and illustrated the mechanistic rationale of its fluorogenic property. Its application to image-based high throughput screening led us to the identification of a new small-molecule modulator of lipid droplet formation. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
