Thermal analysis of anhydrous and hydrated Cholesterol |
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Authors: | Kaloustian J Pauli A-M Lechene de la Porte P Lafont H Portugal H |
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Institution: | (1) Laboratoire de Chimie Analytique, Faculté de Pharmacie, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France;(2) Inserm Unité 476 (Nutrition Humaine et Lipides), Faculté de Médecine, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France |
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Abstract: | Cholesterol constitutes the major component of most gallstones. It was identified and determined, in gallstones, issued from
eleven patients, by thermal analysis: differential scanning calorimetry (DSC), with the use of the melting temperature and
enthalpy, thermogravimetry (TG), with the mass loss of water. Anhydrous cholesterol (ChA) was characterized by two endothermic
peaks (polymorphic, melting) and cholesterol monohydrate (ChH) by two endothermic peaks (dehydration, melting), too. Cha needle
and Chh plate crystals were observed under polarizing light microscopy. The numerous stones obtained from nine patients were
cholesterol stones: the ChA was higher 45 and lower 96%. ChH was present in stones of three patients.
This revised version was published online in July 2006 with corrections to the Cover Date. |
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Keywords: | DTA melting DSC hydrated cholesterol TG gallstones anhydrous cholesterol |
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