| Abstract: | A series of 3-(substituted Methyl)-2-phenyl-4H-l-benzothiopyran-4-ones (thioflavones) and thioflavone 1,1-dioxides was prepared to test for antimicrobial activity and for antitumor activity. It was shown that an introduction of a substituted methyl group in the 3-position of thioflavone resulted in significant antimicrobial activity against Trichophytons. 3-(Acetoxymethyl)thioflavone shows the most antimicrobial potency in vitro against Trichophyton mentagrophytes. Most of the thioflavone 1,1-dioxides showed antimicrobial activity against fungi. Five of the 40 related compounds demonstrated weak antitumor activity against P-388 lymphocytic leukemia. |
