Nucleoside und Nucleotide. Teil 22. Synthese eines Tridecanucleosiddodecaphosphats,das die unnatürliche Base 2(1H)-Pyrimidinon enthält

Nucleosides and Nucleotides. Part 22. Synthesis of a Tridecanucleoside Dodecaphosphate Containing the Unnatural Base 2(1H)-Pyrimidinone The tridecanucleosid dodecaphosphate d(TpTpMpCpGpTpCpApApApApTpC incorporating the modified nucleoside 1-(2′-deoxy-β-D-ribofuranosyl)-2(1H)-pyrimidione (M_d, 2 ) was synthesized using the triester method. The intermediates were the suitably protected trimer d(TpTpM) and the pentamer d(TpTpMpCpG). The latter was condensed with the protected octamer d(TpCpApApApApTpC) to yield the desired tridecanucleotide.