Synthesis of pyrrolo[2,1-c][1,4]benzoxazepines. 1. A novel heterocyclic ring system

The synthesis of a novel pyrrolo[2,1-c][1,4]benzoxazepine ring system (II) by a nucleophilic aromatic fluoride displacement-cyclization is described. Aminoalkyl derivatives were prepared by either the Mannich reaction, or Vilsmeier formylation to provide the 3-formyl derivative which was further elaborated.