| Abstract: | Opianic acid reacts with various hydrazines to yield either hydrazone ( 3, 6 ) or phthalazinone ( 4 ) derivatives depending upon the electronic properties of the substituent attached to the hydrazine molecule. Oxidative cyclization of opianic acid aroylhydrazones with iodine and yellow mercuric oxide gave the 1,3,4-oxadiazole derivatives 21 . The aroylhydrazones were also condensatively cyclized by heating with acetic anhydride to give the 1,3,4-oxadiazoline derivatives 24 . Structures assigned to the prepared compounds were corroborated by studying their chemical as well as their spectral characteristics. |
