Zur Kenntnis des Faktors F430 aus methanogenen Bakterien: Absolute Konfiguration

Factor F430 from Methanogenic Bacteria: Absolute Configuration Experiments on F430M ( 2 ) aiming at a potentially biomimetic, reductive reconstruction of the F430 ( 1 ) chromophore from corresponding pyrrocorphinate intermediates provided us with F430 derivatives which contain an isobacteriochlorinate chromophore system similar to the one occurring in sirohydrochlorin ( 3 ) (cf. the Scheme). Comparison of their CD spectra with the-CD spectrum of nickel( II )-sirohydrochlorinate octamethyl ester demonstrates that the absolute configurations of factor F430 and sirohydrochlorin in the region of rings A and B are the same.