| Abstract: | By oxidative cyclization of 5,5′-arylmethylenebis(6-methylaminouracil) derivatives with diethyl azodicarb-oxylate a number of 5-deazaisoalloxazines were synthesized having at the C(8) position a substituent that causes a bathochromic shift varying between 20 and 130 nm, depending on the substituent. To increase the solubility in aqueous media 8-substituted 5-deazaflavins were prepared having a carboxymethyl group at the N(3) position. The carboxymethyl group was introduced prior to the oxidative cyclization. |
