Synthesis of 4,5-dihydro-4-phenyl-3H-1,3,4-benzotriazepines |
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Authors: | Lawrence L Martin Marc N Agnew Linda L Setescak |
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Abstract: | Several 4,5-dihydro-4-phenyl-3H-1,3,4-benzotriazepines were synthesized by conversion of 1-(2-nitrophenyl)methyl]-1-phenylhydrazine to either 1-(2-aminophenyl)methyl]-1-phenylhydrazine or 1-(2-aminophenyl)-methyl]-2-methyl-1-phenylhydrazine. Ring closure of these intermediates with triethyl orthoacetate or triethyl orthopropionate gave the title compounds in overall yields of 40-60%. |
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