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Projection screen or video goggles as stimulus modality in functional magnetic resonance imaging
Authors:Engström Maria  Ragnehed Mattias  Lundberg Peter
Institution:1. Department of Molecular Microbiology and Infectious Diseases, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States;2. Department of Biological Sciences, College of Arts and Sciences, Florida International University, Miami, FL, United States;3. Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, United States;4. Harvard Partners Center for Genetics and Genomics, Boston, MA, United States;1. Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;2. Laboratory of Marine Natural Products Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East Branch, Russian Academy of Sciences, Vladivostok, Russian Federation;3. Department of Medical Biochemistry and Molecular Biology, University of Greifswald, Greifswald, Germany;4. Interfacultary Institute of Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald, Greifswald, Germany;5. Division of Hematology, University Hospital Zurich, Zurich, Switzerland;1. Department of Biological Science, Florida State University, Tallahassee, FL, USA;2. College of Medicine, Florida State University, Tallahassee, FL, USA;1. Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica;2. Departamento de Biología, Grupo de Investigaciones Herpetológicas y Toxinológicas, Museo de Historia Natural, Universidad del Cauca, Popayán, Colombia;3. Departamento de Biología, Universidad del Tolima, Ibagué, Colombia;4. Centro de Investigaciones Biomédicas, Universidad del Cauca, Popayán, Colombia
Abstract:The purpose of this study was to investigate the reliability of functional magnetic resonance imaging (fMRI) by using either a projection screen or video goggles as stimulus modality. A sequence of visual stimuli were presented to the same subject at different occasions. The sequence was optimized with a genetic algorithm. In five sessions the stimuli were presented using a projection screen viewed through a mirror in the head coil and in five sessions using video goggles. Failure to detect visual activation in the medial left hemisphere was observed in sessions using the projection screen as stimulus modality. Decreased thresholds for P values and cluster size resulted in activation outside the occipital lobe and did not significantly increase activated areas in this region. Results in this study indicate that presentation of fMRI tasks with visual routes is more reliable with direct input through video goggles than with the conventional use of projection screens. Failure to detect crucial visual areas has severe consequences for tumor surgery in the visual cortex. Inferior visual impression might also have negative consequences for cognitive tests with high demand on attention and perception.
Keywords:
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