Regioselective synthesis of substituted pyrroles: efficient palladium-catalyzed cyclization of internal alkynes and 2-amino-3-iodoacrylate derivatives |
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| Authors: | Crawley Matthew L Goljer Igor Jenkins Douglas J Mehlmann John F Nogle Lisa Dooley Rebecca Mahaney Paige E |
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| Institution: | Discovery Medicinal Chemistry and Discovery Analytical Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. crawlem@wyeth.com |
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| Abstract: | The first efficient and regioselective palladium-catalyzed cyclization of internal alkynes and 2-amino-3-iodoacrylates to give moderate to excellent yields of highly functionalized pyrroles has been developed. This approach is applicable to a range of alkynes and affords the deacylated pyrrole under reaction conditions for most substrates. reaction: see text] |
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