NMR relaxation investigation of water “ordering” in aqueous lysozyme solutions

Lysozyme in aqueous dilute solution has been chosen as a model system to investigate the state and the mobility of water molecules near macromolecular surfaces. The dependence of the water proton NMR T₁ on temperature and on denaturing processes is interpreted in terms of long-range interactions giving rise to“ordering” of water, as seen on the NMR time scale.