Some structural and dynamical properties of multilamellar vesicles incorporated with propranolol |
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Authors: | G Albertini C Donati F Rustichelli R S Phadke |
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Institution: | (1) Dipartimento di Scienze dei Materiali e della Terra, Ancona, Italia;(2) Istituto di Fisica Medica, Ancona, Italia;(3) Chemical Physical, Tata Institute of Fundamental Research, 400 005 Bombay, India |
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Abstract: | Summary Spin labelling ESR, calorimetry and31P NMR have been used to investigate dipalmitoyl phosphatidylcholine dispersions incorporated with propranolol which is a β-adrenoceptor
blocking drug, widely used in the treatment of arrhythmy. The drug appears to enter the lipid bilayer also at the lowest concentrations
and to induce a progressive fluidification of multilamellar vesicles. In fact, the presence of drug reduces the temperature
of chain melting transition and the corresponding cooperation number. Furthermore the phase transitionL
β′
−P
β′
is not observable also at the lowest drug concentrations.
Work presented at the First USSR-Italy Bilateral Meeting on Liquid Crystals held in Portonovo, Ancona (Italy), September 30–October
2, 1987. |
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Keywords: | Liquid crystals |
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