Synthesis and Anticancer Activity of Long-Chain Isonicotinic Ester Ligand-Containing Arene Ruthenium Complexes and Nanoparticles |
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| Authors: | Georg Süss-Fink Farooq-Ahmad Khan Lucienne Juillerat-Jeanneret Paul J Dyson Anna K Renfrew |
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| Institution: | 1.Institut de Chimie,Université de Neuchatel,Neuchatel,Switzerland;2.University Institute of Pathology, Centre Hospitalier Universitaire Vaudois (CHUV),Lausanne,Switzerland;3.Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL),Lausanne,Switzerland |
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| Abstract: | Arene ruthenium complexes containing long-chain N-ligands L1 = NC5H4–4-COO–C6H4–4-O–(CH2)9–CH3 or L2 = NC5H4–4-COO–(CH2)10–O–C6H4–4-COO–C6H4–4-C6H4–4-CN derived from isonicotinic acid, of the type (arene)Ru(L)Cl2] (arene = C6H6, L = L1: 1; arene = p-MeC6H4Pr
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, L = L1: 2; arene = C6Me6, L = L1: 3; arene = C6H6, L = L2: 4; arene = p-MeC6H4Pr
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, L = L2: 5; arene = C6Me6, L = L2: 6) have been synthesized from the corresponding (arene)RuCl2]2 precursor with the long-chain N-ligand L in dichloromethane. Ruthenium nanoparticles stabilized by L1 have been prepared by the solvent-free reduction of 1 with hydrogen or by reducing (arene)Ru(H2O)3]SO4 in ethanol in the presence of L1 with hydrogen. These complexes and nanoparticles show a high anticancer activity towards human ovarian cell lines, the highest
cytotoxicity being obtained for complex 2 (IC50 = 2 μM for A2780 and 7 μM for A2780cisR). |
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