Au(I)- and Pt(II)-catalyzed cycloetherification of omega-hydroxy propargylic esters |
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| Authors: | De Brabander Jef K Liu Bo Qian Mingxing |
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| Institution: | Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9038, USA. jef.debrabander@utsouthwestern.edu |
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| Abstract: | Depending on the nature of the metal catalyst, omega-hydroxy propargylic acetates choose between alternative cycloetherification manifolds to produce functionalized heterocycles in high yields. AuCl catalyzes the formation of oxacyclic enol acetates, whereas Cl(2)Pt(CH(2)CH(2))]2 (Zeise's dimer) will induce a propargylic substitution via an unprecedented S(N)2'-type allenic substitution from within a chelated square planar cationic Pt(II) complex. |
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